Publications

▼2024年


Nishito Y, Fujishiro H, Nagamatsu S, Kambe T
"Reduced Mn uptake of pleiotropic ZIP8 SNP is caused by its loss of Mn-responsive
accumulation on the cell-surface"
Biosci Biotechol Biochem, in press

Cheng R, Nishikawa Y, Wagatsuma T, Kambe T, Tanaka YK, Ogra Y, Tamura T,
Hamachi I
"Protein-Labeling Reagents Selectively Activated by Copper(I)"
ACS Chem Biol, in press

Yuasa H, Morino N, Wagatsuma T, Munekane M, Ueda S, Matsunaga M, Uchida Y,
Katayama T, Katoh T, Kambe T
"ZNT5-6 and ZNT7 have an integral role in protein N-glycosylation through supplying
Zn2+ to Golgi α-mannosidase II"
J. Biol. Chem, 300, 107378, 2024

Nishito Y, Kamimura Y, Nagamatsu S, Yamamoto N, Yasui H, Kambe T
"Zinc and manganese homeostasis closely interact in mammalian cells"
FASEB J. 38, e23605, 2024

Sakata KI, Hashimoto A, Kambe T, Sato J, Ohga N, Yamazaki Y, Koyachi M,
Tatsuki I, Okada M, Taro O, Hikasa H, Kitagawa Y
"Expression analysis of zinc-metabolizing enzymes in the saliva as a new method of
evaluating zinc content in the body: two case reports and a review of the literature"
J Med Case Rep. 18, 198, 2024

神戸大朋
「分泌経路における銅酵素と亜鉛酵素の活性化機構」
生体の科学 特集 (生命現象を駆動する生体内金属動態の理解と展開) 75, 143-147, 2024

Okumura Y, Abe K, Sakai S, Kamei Y, Mori Y, Adachi Y, Takikawa M, Kitamura A,
Ohminami H, Ohnishi K, Masuda M, Kambe T, Yamamoto H, Taketani Y
"Elevated luminal inorganic phosphate suppresses intestinal Zn absorption in 5/6
nephrectomized rats"
Am J Physiol Renal Physiol. 326, F411-F419, 2024

Kakita N, Katayama K, Yasui T, Satake S, Aoi K, Jo H, Kim YK, Yamazaki M,
Hashimoto A, Kambe T
"Zinc transporter 1 expression in hepatocellular carcinoma correlates with prognosis: A
single-center retrospective study."
J Trace Elem Med Biol. 82,127354,2024

▼2023年


Kambe T, Wagatsuma T
"Metalation and activation of Zn2+ enzymes via early secretory pathway-resident ZNT
proteins"
Biophysics Reviews, 4, 041302, 2023

神戸大朋
「メラニン生合成における亜鉛の重要性」
亜鉛栄養治療, 14, 16-23, 2023

神戸大朋
「亜鉛欠乏症のメカニズム:細胞外ATP代謝制御障害とアデノシンの減少」
脳神経内科, 99, 787-792, 2023

神戸大朋
「黒いメラニン色素生合成における亜鉛要求性の発見」(トピックス)
バイオサイエンスとインダストリー, 81, 518-519, 2023

神戸大朋
「メラニン色素生合成には亜鉛が必要である」(目で見るバイオ)
バイオサイエンスとインダストリー, 81, 488-489, 2023

Nishito Y, Hashimoto A, Kambe T
"Simple in vitro method to evaluate ZIP zinc transport ability through zinc transporter 1
and metallothionein expression measurements"
Methods Enzymol., 687: 207-239, 2023

神戸大朋
「亜鉛トランスポーターの解析から亜鉛の生理機能を探る」
日本栄養・食糧学会誌, 76, 207-216, 2023

Ikeda Y, Kawakami M, Yamada Y, Munekane M, Sano K, Mukai T, Kambe T,
Shitan N
"Chloroform Fraction of Panax Ginseng Extract Enhances Zip4-Mediated Zinc
Influx into the Cytosol"
BPB Reports, 6, 108-114, 2023

神戸大朋
「亜鉛による生体機能制御」
実験医学増刊 精密栄養学, 41, 144-149, 2023

Sato S, Yamamato K, Ito M, Nishino K, Otsuka T, Irie K, Nagao M
"Enhancement of Inhibitory Activity by Combining Alloteric Inhibitors Putatively Binding
to Different Allosteric Sites on Cathepsin K"
Molecules, 28, 4197, 2023

Wagatsuma T, Suzuki E, Shiotsu M, Sogo A, Nishito Y, Ando H, Hashimoto H,
Petris MJ, Kinoshita M, Kambe T
"Pigmentation and TYRP1 expression are mediated by zinc through the early secretory
pathway-resident ZNT proteins"
Commun. Biol., 6, 403, 2023

Nishino K, Someya K, Tsukano C, Ishikawa T, Nagao M
"Synthesis of 8β-hydroxy-9(11), 13-abietadien-12-one from (+)-dehydroabietylamine
and its AhR ligand activity"
Results in Chemistry, 5, 100912, 2023

Muto T, Kawase Y, Aiba K, Okuma M, Itsumura N, Luo S, Ogawa N, Tsuji T,
Kambe T
"Novel SLC30A2 mutations in the pathogenesis of transient neonatal zinc deficiency"
Pediatr. Investig., 7, 6-12, 2023

神戸大朋
「初期分泌経路でのタンパク質成熟化における亜鉛の重要性」
ファルマシア, 59, 212-216, 2023

▼2022年


Tanaka K, Taketani Y, Angeles-Agdeppa I, Kambe T
"Role of Vitamins and Minerals in Health and Diseases"
J. Nutr. Sci. Vitaminol., 68, S70-S72, 2022

Sim EZ, Enomoto T, Shiraki N, Furuta N, Kashio S, Kambe T, Tsuyama T,
Arakawa A, Ozawa H, Yokoyama M, Miura M, Kume S
"Methionine metabolism regulates pluripotent stem cell pluripotency and
differentiation through zinc mobilization"
Cell Rep. 40, 111120, 2022

Fujishiro H, Miyamoto S, Sumi D, Kambe T, Himeno S
"Effects of individual amino acid mutations of zinc transporter ZIP8 on manganese-
and cadmium-transporting activity"
Biochem. Biophys. Res. Commun. 616, 26-32, 2022

Wagatsuma T, Shimotsuma K, Sogo A, Sato R, Kubo N, Ueda S, Uchida Y,
Kinoshita M and Kambe T
"Zinc transport via ZNT5-ZNT6 and ZNT7 is critical for cell surface
glycosylphosphatidylinositol-anchored protein expression"
J. Biol. Chem. 298, 102011, 2022

Nagamatsu S, Nishito Y, Yuasa H, Yamamoto N, Komori T, Suzuki T, Yasui H
and Kambe T
"Sophisticated expression responses of ZNT1 and MT in response to changes in the
expression of ZIPs"
Sci. Rep. 12, 7334, 2022

Ueda S, Manabe Y, Kubo N, Morino N, Yuasa H, Shiotsu M, Tsuji T, Sugawara T
and Kambe T
"Early secretory pathway-resident Zn transporter proteins contribute to celluler
sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1"
Am J Physiol Cell Physiol, 322, C948-C959, 2022

神戸大朋
「亜鉛メタレーションによる細胞機能調節」
実験医学増刊 栄養・代謝物シグナルと食品機能, 40, 38-44, 2022

Hashimoto A and Kambe T
"Overview of the zinc absorption mechanism for improving zinc nutrition"
Metallomics Research, 2, MR202115, 2022

Ikeda Y, Munekane M, Yamada Y, Kawakami M, Amano I, Sano K, Mukai T,
Kambe T and Shitan N
"Enhancing effect of Panax ginseng on Zip4-mediated zinc influx into the cytosol"
J Ginseng Res. 46, 248-254, 2022

Kelleher SL, Alam S, Rivera OC, Barber-Zucker S, Zarivach R, Wagatsuma T,
Kambe T, Soybel DI, Wright J, Lamendella R
“Loss-of-function SLC30A2 mutants are associated with gut dysbiosis and alterations
in intestinal gene expression in preterm infants”
Gut Microbes, 14, 2014739, 2022

神戸大朋
健康維持に不可欠なミネラル・亜鉛の機能を探る
化学と生物, 60, 22-29, 2022

Fujishiro H and Kambe T
“Manganeze transport in mammals by zinc transporter family proteins, ZNT and ZIP”
J. Pharmacol. Sci. 148, 125-133, 2022

▼2021年


Hasegawa T, Osaka M, Miyamae Y, Nishino K, Isoda H, Kawada K, Neffati M,
Irie K, Nagao M
"Two Types of PPARγ Ligands Identified in the Extract of Artemisia campestris"
Chemistry, 3, 647-657, 2021

橋本彩子、神戸大朋
「消化管での亜鉛吸収機構に着目した亜鉛栄養の改善」
Trace Nutrients Research- 微量栄養素研究-, 38, 85-90, 2021

神戸大朋、辻徳治
「亜鉛の生体機能と細胞内輸送機構」
金属, 91, 38-44, 2021

神戸大朋
「ミネラルの働き」
食品免疫学事典、日本食品免疫学会(編)
朝倉書店 34-35, 2021

神戸大朋
「亜鉛欠乏症の病態」
日本医師会雑誌, 150, 464, 2021

森野菜穂、神戸大朋
「アルカリホスファターゼの活性化には亜鉛トランスポーターが重要な役割を果たす」
亜鉛栄養治療, 11, 13-21, 2021

Kambe T, Taylor KM, and Fu D
“Zinc transporters and their functional integration in mammalian cells”
J. Biol. Chem., 296, 100320, 2021

Tsuji T, Morita SY, Nakamura Y, IkedaY, Kambe T, Terada T
“Alterations in cellular and organellar phospholipid compositions of HepG2 cells during
cell growth”
Sci. Rep., 11, 2731, 2021

西藤有希奈、神戸大朋
「マンガン代謝維持機構における輸送体の役割 ―マンガン輸送体の輸送金属識別機構―」
生命金属ダイナミクス 生体内における金属の挙動と制御、監修:城 宜嗣、津本 浩平、編
集委員:古川良明、神戸 大朋
株式会社エヌ・ティー・エス, 58-65, 2021

神戸大朋
「生体内での亜鉛の機能とその代謝」
生命金属ダイナミクス 生体内における金属の挙動と制御、監修:城 宜嗣、津本 浩平、編
集委員:古川良明、神戸 大朋
株式会社エヌ・ティー・エス, 13-20, 2021

Yanagimichi M, Nishino K, Sakamoto A, Kurodai R, Kojima K, Eto N, Isoda H,
Ksouri R, Irie K, Kambe T, Masuda S, Akita T, Maejima K, Nagao M.
“Analyses of putative anti-cancer potential of three STAT3 signaling inhibitory
compounds derived from Salvia officinalis”
Biochem Biophys Rep. 25, 100882, 2021

Stocks CJ, von Pein JB, Curson JEB, Rae J, Phan MD, Foo D, Bokil NJ, Kambe T,
Peters KM, Parton RG, Schembri MA, Kapetanovic R, Sweet MJ
“LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against
intracellular Escherichia coli”
J Leukoc Biol, 109, 287-297, 2021

Nishino K#, Someya K#, Ksouri R, Ishikawa T, Isoda H, Irie K, Nagao M (#equally contribute)
“Abietane diterpenoids from Salvia officinalis leaves as aryl hydrocarbon receptor ligands.”
Phytochem. Lett., 41, 78, 2021

▼2020年


神戸大朋
亜鉛の基礎科学
Visual Dermatology, 19, 1010-1013, 2020

Suzuki E#, Ogawa N#, Takeda T#, Nishito Y#, Tanaka Y, Fujiwara T, Matsunaga M,
Ueda S, Kubo N, Tsuji T, Fukunaka A, Yamazaki T, Taylor KM, Ogra Y, and Kambe T
(#equally contribute)
“Detailed analyses of the crucial functions of Zn transporter proteins in alkaline
phosphatase activation”
J. Biol. Chem., 295, 5669-5684, 2020

Fukada T* and Kambe T* (*Corresponding author)
“Report for the Sixth Meeting of the International Society for Zinc Biology (ISZB-2019)”
Int J Mol Sci., 21, 611, 2020

神戸大朋
「亜鉛の体内での働き・亜鉛欠乏症の基礎的病態」
細胞 52, 113-115, 2020

神戸大朋
「微量元素の調節機構」
腎臓内科11, 107-114, 2020

Kambe T
“Metalation and maturation of zinc ectoenzymes: A perspective”
Biochemistry, 59, 74-79, 2020

Nishino K, Uesugi H, Hirasawa A, Ohtera A, Miyamae Y, Neffati M, Isoda H, Kambe
T, Masuda S, Irie K, Nagao M.
“Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells
through FFAR1”
Biochem Biophys Res Commun., 522, 68-73, 2020

Kambe T and Takahashi M
“Biological functions of soyasaponins: The potential use to improve zinc nutrition”
Nuts and Seeds in Health and Disease, Second Edition
Preedy V.R. and Watson R.R. (eds): Elsevier, 93-102, 2020

Nishito Y, Luo S, and Kambe T
“Zinc transporters involved in vectorial zinc transport in intestinal epithelial cells”
Ion Channels and Transporters of Epithelia in Heatllh and Disease-2nd Edition
Hamilton K.L. and Devor D.C. (eds).
Springer, 447-465, 2020

▼2019年


Nishito Y, and Kambe T
“Zinc transporter 1 (ZNT1) expression on the cell surface is elaborately controlled by cellular
zinc levels”
J. Biol. Chem., 294, 15686-15697, 2019

上田祥子、神戸大朋
「エクト型亜鉛要求性酵素の活性化機構:亜鉛栄養を絡めた考察」
Trace Nutrients Research-微量栄養素研究-, 36, 102-105, 2019

Zinc transporters-A review and a new view from biochemistry
Kambe T, Suzuki E, Komori T
Zinc Signaling-Second Edition
Fukada T. and Kambe T. (eds). Springer-Nature, 23-56, 2019

西藤有希奈、神戸大朋
「亜鉛輸送体の亜鉛状態に応答した発現および局在の制御機構」
亜鉛栄養治療, 10, 25-31, 2019

Katano H, Noba S, Taira S, Kambe T and Takahashi M
“A Solubility-Based Separation of Group B Soyasaponins from the Whole Soybean Flour”
Anal. Sci., 35, 935-937, 2019

神戸大朋
「亜鉛トランスポーターを介したエクト型亜鉛要求性酵素の活性化」
食品・バイオにおける最新の酵素応用, シーエムシー出版, 231-238, 2019

西藤有希奈、橋本彩子、神戸大朋
「必須微量金属の消化管吸収の分子機構」
消化器・肝臓内科, 5, 475-482, 2019

Ogawa Y, Kinoshita M, Shimada S, Kambe T, and Kawamura T
“Zinc transporters in the epidermis”
J Dermatol, 46, e243-e245, 2019

武田貴成、笹川剛、駒井三千夫、神戸大朋
「細胞外アデニンヌクレオチド分解活性は亜鉛栄養状態を反映する」
栄養-Trends of Nutrition-, 4, 47-49, 2019

▼2018年


西藤有希奈、直木志保、神戸大朋
「生体内の亜鉛代謝制御における亜鉛輸送体の役割」
微量栄養素研究-, 35, 92-97, 2018

神戸大朋、長尾早枝子、福江和久、廣瀬潤子
「母乳中亜鉛の重要性を考える:亜鉛トランスポーターの変異と母乳中亜鉛量の調査報告」
亜鉛栄養治療, 9, 28-35, 2018

武田貴成、神戸大朋
「亜鉛要求性酵素による細胞外ATP代謝の制御」
亜鉛栄養治療, 9, 22-27, 2018

神戸大朋
「日本人女性の遺伝子変異と乳児亜鉛欠乏症」
食と医療54-59, 2018

神戸大朋
「亜鉛栄養とヒトの健康」
アグリバイオ, 2, 1154-1158, 2018

Fukue K, Itsumura N, Tsuji N, Nishino K, Nagao M, Narita H and Kambe T
“Evaluation of the roles of the cytosolic N-terminus and His-rich loop of ZNT proteins using ZNT2 and ZNT3 chimeric mutants”
Sci. Rep., 8, 14084, 2018

Ogawa Y, Kinoshita M, Mizumura N, Miyazaki S, Aoki R, Momosawa A, Shimada S, Kambe T, Kawamura T.
“Purinergic Molecules in the Epidermis”
J Invest Dermatol, 138, 2486-2488, 2018

Takeda T, Miyazaki S, Kobayashi M, Nishino K, Goto T, Matsunaga M, Ooi M, Shirakawa H, Tani F, Kawamura T, Komai M, and Kambe T
“Zinc deficiency causes delayed ATP clearance and adenosine generation in rats and cell culture models” Commun Biol, 1, 113, 2018

駒井三千夫、後藤知子、大日向耕作、神戸大朋、真柳祐希、白川 仁
消化管亜鉛シグナルによる食欲亢進作用のメカニズム
YAKUGAKU ZASSHI, 138, 1011-1016, 2018

武田貴成、神戸大朋
エクト型亜鉛酵素の亜鉛獲得による活性化機構
生化学, 90(3), 333-339, 2018

Okamura M, Yamanaka Y, Shigemoto M, Kitadani Y, Kobayashi Y, Kambe T, Nagao M, Kobayashi I, Okumura K, and Masuda S
Depletion of mRNA export regulator DBP5/DDX19, GLE1 or IPPK that is a key enzyme for the production of IP6, resulting in differentially altered cytoplasmic mRNA expression and specific cell defect.
PLoS One. 13, e0197165, 2018

Fukada T* and Kambe T* (*Corresponding author)
“Editorial: Welcome to the World of Zinc Signaling”
Int J Mol Sci., 19, 785, 2018

西野勝俊、山口宗義、藤田 徹、東 智則、宜寿次盛生、成松眞樹、山田明義、平井伸博
「抗菌物質・シュウ酸アルミニウムのマツタケシロにおける普遍的存在」
日本きのこ学会誌, 26, 24-27, 2018

Nishito Y and Kambe T
“Absorption mechanisms of iron, copper, and zinc: An overview”
J Nutr Sci Vitaminol., 64, 1-7, 2018

▼2017年


Katsutoshi Nishino, Kaya Matsubara, Chihiro Tanaka, Muneyoshi Yamaguchi, Toru Fujita, Akiyoshi Yamada, Nobuhiro Hirai.
"Seasonal changes in the content of the (oxalato)aluminate complex, an antimicrobial substance of the “shiro” of Tricholoma matsutake, and the bacterial community structure in the shiro area”
Mushroom Sci Biotechnol, 25, 9-16, 2017

神戸大朋
「母乳栄養と亜鉛:亜鉛トランスポーターの変異により引き起こされる乳児亜鉛欠乏症」
生化学, 89, 881‒884, 2017

Kambe T, Matsunaga M and Takeda T
“Understanding the Contribution of Zinc Transporters in the Function of the Early Secretory Pathway”
Int J Mol Sci., 18, 2179, 2017

Kurata M, Morimoto M, Kawamura Y, Mursi IFA, Momma K, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, and Masuda S
“Inhibition of mRNA Maturation by Compounds Which Have a Flavonoid Skeleton”
Biochemistry and Molecular Biology, 2, 46-53, 2017

西藤有希奈、神戸大朋
「消化管での微量金属の吸収調節機構 -鉄、銅、亜鉛の吸収に関わる分子-」
消化と吸収, 39, 122−127, 2017

Golan Y, Kambe T* and Assaraf YG* (*Corresponding author)
“The role of the zinc transporter SLC30A2/ZnT2 in transient neonatal zinc deficiency”
Metallomics, 9, 1352-1366, 2017

Fujishiro H, Hamao S, Tanaka R, Kambe T and Himeno S
“Concentration-dependent roles of DMT1 and ZIP14 in cadmium absorption in Caco-2 cells”
J. Toxicol. Sci., 42, 559-567, 2017

Go S, Kurita H, Yokoo K, Inden M, Kambe T and Hozumi I
“Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium”
Biochem Biophys Res Commun., 490, 1307-1313, 2017

Hara T#, Takeda T#, Takagishi T, Fukue K, Kambe T* and Fukada T* (#equally contribute, *Corresponding author)
“Physiological roles of zinc transporters: molecular and genetic importance in zinc homeostasis”
J Physiol Sci, 67, 283–301, 2017

Tsuji T, Kurokawa Y, Chiche J, Pouyssegur J, Sato H, Fukuzawa H, Nagao M, and Kambe T
“Dissecting the process of activation of cancer-promoting zinc-requiring ectoenzymes by zinc metalation mediated by ZnT transporters”
J. Biol. Chem., 292, 2159–2173, 2017

Kurata M, Murata Y, Momma K, Fouad Ali Mursi I, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, Masuda S.
The isoflavone fraction from soybean presents mRNA maturation inhibition activity”
Biosci Biotechnol Biochem, 81, 551-554, 2017

Katsutoshi Nishino, Misao Shiro, Ryuki Okura, Kazuya Oizumi, Toru Fujita, Takahiro Sasamori, Norihiro Tokitoh, Akiyoshi Yamada, Chihiro Tanaka, Muneyoshi Yamaguchi, Syuntaro Hiradate & Nobuhiro Hirai (B.B.B.論文賞 受賞)
“The (oxalato)aluminate complex as an antimicrobial substance protecting the "shiro" of Tricholoma matsutake from soil micro-organisms”
Biosci Biotechnol Biochem, 81, 102-111, 2017

▼2016年


橋本彩子、有本紗也加、神戸大朋
「消化管における亜鉛トランスポーターZIP4とZIP5の相互発現制御」
Trace Nutrients Research-微量栄養素研究-, 33, 122−127, 2016

小原隆史、小松なぎさ、逸村直也、神戸大朋、武藤雄一郎、西原卓宏、平井克樹、右田昌宏
「母体ZnT2遺伝子変異に基づく低亜鉛母乳による亜鉛欠乏性皮膚炎」
日本小児科学会雑誌, 120, 1649-1656, 2016

神戸大朋
「亜鉛トランスポーター研究から視た亜鉛バイオロジー」
JAACTニュースレター, 26, 4-15, 2016

Kambe T*, Fukada T*, Toyokuni S (*Corresponding author)
“Editorial: The coming of age of zinc biology”
Arch Biochem Biophys., 611, 1-2, 2016

辻徳治、神戸大朋
「分泌型亜鉛要求性酵素の亜鉛獲得・活性化メカニズム」
内分泌・糖尿病・代謝内科, 43, 115-120, 2016

Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T
“The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation”
Biochem. J., 473, 2611–2621, 2016

Miyamae Y#*, Nishito Y#, Nakai N, Nagumo Y, Usui T, Masuda S, Kambe T, Nagao M*
(#equally contribute, *Corresponding author)
“Tetrandrine induces lipid accumulation through blockade of autophagy in a hepatic stellate cell line”
Biochem Biophys Res Commun, 477, 40-46, 2016

橋本彩子、神戸大朋
「亜鉛トランスポーターZIP4を標的とした亜鉛栄養の改善」
亜鉛栄養治療, 6, 67-72, 2016

神戸大朋
「亜鉛トランスポーターを標的にした亜鉛栄養改善」
日本臨牀,74, 1234-1238, 2016

Itsumura N, Kibihara Y, Fukue K, Miyata A, Fukushima K, Tamagawa-Mineoka R, Katoh N, Nishito Y, Ishida R, Narita H, Kodama H, Kambe T
“Novel mutations in SLC30A2 involved in the pathogenesis of transient neonatal zinc deficiency”
Pediatr Res., 80, 586-594, 2016

Nishito Y, Tsuji N, Fujishiro H, Takeda T, Yamazaki T, Teranishi F, Okazaki F, Matsunaga A, Tuschl K, Rao R, Kono S, Miyajima H, Narita H, Himeno S, Kambe T.
“Direct Comparison of Manganese Detoxification/Efflux Proteins and Molecular Characterization of ZnT10 Protein
as a Manganese Transporter”
J. Biol. Chem., 291, 14773-14787, 2016

Golan Y#, Itsumura N#, Glaser F, Berman B, Kambe T*, Assaraf YG*
(# equally contribute, * corresponding author)
“Molecular Basis of Transient Neonatal Zinc Deficiency: Novel ZnT2 Mutations Disrupting Zinc Binding and Permeation”
J. Biol. Chem., 291, 13546–13559, 2016

Kambe T, Nishito Y and Fukue K
“Zinc transporters in health and disease”
Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
J.F. Collins (ed): Elsevier, 283-291, 2016

Kambe T, Takeda T, Nishito Y
“Activation of zinc-requiring ectoenzymes by ZnT transporters during the secretory process: Biochemical and molecular aspects”
Arch Biochem Biophys., 611, 37-42, 2016

Kimura T, Kambe T(Best Review Article prize of the IJMS 2017 Best Paper Award 受賞)
“The Functions of Metallothionein and ZIP and ZnT Transporters: an Overview and Perspective”
Int J Mol Sci,, 17, 336, 2016

Yamada D, Saiki S, Furuya N, Ishikawa KI, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N.
“Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation”
Biochem Biophys Res Commun., 471, 109-116, 2016

Hashimoto A, Nakagawa M, Tsujimura N, Miyazaki S, Kizu K, Goto T, Komatsu Y, Matsunaga A, Shirakawa H, Narita H, Kambe T* and Komai M
( * corresponding author)
“Properties of Zip4 accumulation during zinc deficiency and its usefulness to evaluate zinc status: A study of the effects of zinc deficiency during lactation”
Am J Physiol Regul Integr Comp Physiol., 310, R459-R468, 2016

▼2015年


Ohtera A, Miyamae Y*, Yoshida K, Maejima K, Akita T, Kakizuka A, Irie K, Masuda S, Kambe T, Nagao M*
( * corresponding author)
“Identification of a New Type of Covalent PPARγ Agonist using a Ligand-linking Strategy”
ACS Chem Biol., 10, 2794−2804, 2015

Hashimoto A, Ohkura K, Takahashi M, Kizu K, Narita H, Enomoto S, Miyamae Y, Masuda S, Nagao M, Irie K, Ohigashi H, Andrews G. K and Kambe T
“Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4-targeting”
Biochem. J., 472: 183-193, 2015

Kumar L, Michalczyk A, McKay J, Ford D, Kambe T, Hudek L, Varigios G, Taylor P. E and Ackland M. L
“Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk”
Genes and Nutrition, 10:487, 2015

Hashimoto A and Kambe T
“Mg, Zn and Cu transport proteins: A brief overview from physiological and molecular perspectives”
J Nutr Sci Vitaminol., 61, S116 - S118, 2015

Kambe T, Fukue K, Ishida R, and Miyazaki S
“Overview of inherited zinc deficiency in infants and children”
J Nutr Sci Vitaminol., 61, S44 - S46, 2015

Kambe T, Tsuji T, Hashimoto A, and Itsumura N
“The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism”
Physiol Rev., 95: 749–784, 2015

Gotoh A, Katoh T, Sugiyama Y, Kurihara S, Honda Y, Sakurama H, Kambe T, Ashida H, Kitaoka M, Yamamoto K, and Katayama T
“Novel substrate specificities of two lacto-N-biosidases towards β-linked galacto-N-biose-containing oligosaccharides of globo H, Gb5, and GA1”
Carbohydr Res., 408, 18–24, 2015

深田俊幸、神戸大朋
「なぜ亜鉛は生命に必要なのか? 亜鉛生物学の潮流と今後の課題について」
細胞工学, 34, 310-316, 2015

Katano H, Okamoto N, Takakuwa M, Taira S, Kambe T and Takahashi M
“Simple and Rapid Separation of Soyasaponin Bb from a Soy Extract”
Analytical Sciences. 31, 85-89, 2015

Park SL, Won SY, Song JH, Kambe T, Nagao M, Kim WJ, Moon SK
“EPO gene expression promotes proliferation, migration and invasion via the p38MAPK/AP-1/MMP-9 pathway by p21WAF1 expression in vascular smooth muscle cells”
Cell Signal. 27, 470-478, 2015

Kaneko M, Noguchi T, Ikegami S, Sakurai T, Kakita A, Toyoshima Y, Kambe T, Yamada M, Inden M, Hara H, Takahashi H and Hozumi I
“Zinc Transporters (ZnT3 and 6) Are Downregulated in the Spinal Cords of Patients with Sporadic Amyotrophic Lateral Sclerosis”
J Neurosci Res. 93, 370-379, 2015

▼2014年


神戸大朋、宮﨑志保
「分泌経路で成熟する亜鉛要求性酵素活性化の分子機構」
日本応用酵素協会誌, 49, 9-15, 2014

神戸大朋
「亜鉛栄養と亜鉛トランスポーター」
ビタミン, 88, 560-564, 2014

Kambe T, Tsuji T and Fukue K
“Zinc Transport Proteins and Zinc Signaling”
Zinc Signals in Cellular Functions and Disorders,
Fukada T, Kambe T (eds). Tokyo: Springer, Springer, 27-53, 2014

Kambe T
“Introduction: “Zinc Signaling”–The Blossoming Field of Zinc Biology”
Zinc Signals in Cellular Functions and Disorders,
Fukada T, Kambe T (eds). Tokyo: Springer, 1-5, 2014

Bin BH, Hojyo S, Hosaka T, Bhin J, Kano H, Miyai T, Ikeda M, Kimura-Someya T, Shirouzu M, Cho EG, Fukue K, Kambe T, Ohashi W, Kim KH, Seo J, Choi DH, Nam YJ, Hwang D, Fukunaka A, Fujitani Y, Yokoyama S, Superti-Furga A, Ikegawa S, Lee TR, Fukada T
“Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins”
EMBO Mol Med. pii: e201303809, 2014

辻徳治、神戸大朋
「亜鉛トランスポーターの特徴と生理機能– ZIP, ZnTトランスポーターと細胞機能・疾患との関連性 –」
生体の科学, 65, 370-378, 2014

橋本彩子、神戸大朋
「食品と亜鉛−健康を保つための亜鉛摂取」
Functional Food, 25, 48-51, 2014

Kambe T, Hashimoto A, and Fujimoto S
“Current understanding of ZIP and ZnT zinc transporters in human health and diseases”
Cell. Mol. Life. Sci., 71, 3281-3295, 2014

逸村直也、神戸大朋
「乳児亜鉛欠乏症を引き起こす低亜鉛母乳と亜鉛トランスポーターZnT2の変異」
Biomed. Res. Trace Elements - 日本微量元素学会誌, 25, 1-7, 2014

神戸大朋
「有害物質の膜輸送とトランスポーター」
毒性の科学 − 分子・細胞から人間集団まで, 熊谷嘉人, 姫野誠一郎, 渡辺知保 編
東京大学出版会, 24-27, 2014

Kambe T
“Methods to Evaluate Zinc Transport into and out of the Secretory and Endosomal-Lysosomal Compartments in DT40 Cells”
Methods Enzymol. 534, 77-92, 2014

▼2013年


Kambe T
“Regulation of zinc transport”
Encyclopedia of Inorganic and Bioinorganic Chemistry,
Edited by V. Culotta and R. A. Scott. John Wiley & Sons, Ltd: Chichester, UK, 301-309, 2013

神戸大朋
「ZnT亜鉛トランスポーターの早期分泌経路における役割」
Biomed. Res. Trace Elements-日本微量元素学会誌, 24, 110-116, 2013

Fujimoto S* , Itsumura N* , Tsuji T, Anan Y, Tsuji N, Ogra Y, Kimura T, Miyamae Y, Masuda S, Nagao M and Kambe T
( * equally contributing authors)
“Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway”
PLOS ONE, 8, e77445, 2013

Ohtera A, Miyamae Y, Nakai N, Kawachi A, Kawada K, Han J, Isoda H, Neffati M, Akita T, Maejima K, Masuda S, Kambe T, Mori N, Irie K, Nagao M
“Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist”
Biochemical and Biophysical Research Communications, 440, 204-209, 2013


Itsumura N, Inamo Y, Okazaki F, Teranishi F, Narita H, Kambe T* and Kodama H
( * corresponding author)
“Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant”
PLOS ONE, 8, e64045, 2013

神戸大朋
「亜鉛代謝の必須分子として機能する亜鉛トランスポーター」
日本衛生学雑誌, 68, 92-102, 2013

神戸大朋
「消化管における亜鉛吸収のメカニズム」
亜鉛の機能と健康ー新たにわかった多彩な機能,
日本栄養・食糧学会監修, 駒井三千夫・神戸大朋 責任編集, 健帛社, 151-168, 2013

神戸大朋
「今後の展望」
亜鉛の機能と健康ー新たにわかった多彩な機能,
日本栄養・食糧学会監修, 駒井三千夫・神戸大朋 責任編集, 健帛社, 223-233, 2013

Taniguchi M, Fukunaka A, Hagihara M, Watanabe K, Kamino S, Kambe T, Enomoto S, Hiromura M
“Essential role of the zinc transporter ZIP9/SLC39A9 in regulating the activations of Akt and Erk in B-cell receptor signaling pathway in DT40 cells”
PLOS ONE, 8, e58022, 2013

▼2012年


橋本彩子、神戸大朋
「亜鉛吸収を向上させる食品因子の探索-亜鉛栄養研究の現状と今後の展望を含めて-」
日本醸造協会誌, 197, 836-841, 2012

Kambe T
“Molecular Architecture and Function of ZnT transporters”
Current Topics in Membranes-Metal Transporters, 69, 199–220, 2012
S. Lutsenko & J. M. Argüello (Eds.), Elsevier Inc.: Academic Press

Fujita K, Okamura M, Nishimoto S, Kurihara T, Momma K, Miyamae Y, Kambe T, Nagao M, Narita H, Masuda S
“Establishment of a monitoring system to detect inhibition of mRNA processing”
Biosci Biotechnol Biochem. 76, 1248-1251, 2012

Miyamae, Y.; Kurisu, M.; Murakami, K.; Han, J.; Isoda, H.; Irie, K.; Shigemori, H.
”Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of 42-residue amyloid β protein”
Bioorg. Med. Chem., 20, 5844-5849, 2012

韓畯奎、宮前友策、繁森英幸、礒田博子
「カフェオイルキナ酸は神経細胞保護作用を持つ」
化学と生物 50, 77-79, 2012

▼2011年


神戸大朋
「早期分泌経路における亜鉛酵素の活性化機構-ZnT複合体による2-step mechanismを介したTNAPの活性化-」
Biomed. Res. Trace Elements-日本微量元素学会誌, 22, 66-72, 2011

橋本彩子、辻徳治、逸村直也、神戸大朋
「消化管における必須微量金属の吸収-トランスポーターによる制御機構-」
Trace Nutrients Research-微量栄養素研究-, 28, 89-94, 2011

橋本彩子、神戸大朋
「味噌など大豆発酵食品による亜鉛栄養改善の可能性-亜鉛吸収に機能するトランスポーターの発現に及ぼす効果-」
日本醸造協会誌, 106, 811-817, 2011

神戸大朋
「必須微量ミネラルの体内ホメオスタシスには臓器間のコミュニケーションが重要?」
ネスレ栄養科学会議-栄養科学トピックス, 2011
http://www.j.nestle.co.jp/science/topics/topics1107_2.asp

Kambe T
“An Overview of a Wide Range of Functions of ZnT and Zip Zinc Transporters in the Secretory Pathway”
Biosci. Biotechnol. Biochem., 75, 1036-1043, 2011

Fukunaka A, Kurokawa Y, Teranishi F, Sekler I, Oda K, Ackland M. L, Faundez V, Hiromura M, Masuda S, Nagao M, Enomoto S and Kambe T
“Tissue non-specific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway”
J. Biol. Chem., 286, 16363-16373, 2011

Fukada T and Kambe T
“Molecular and genetic features of zinc transporters in physiology and pathogenesis”
Metallomics, 3, 662-674, 2011

Aihara Y, Fujiwara N, Yamazaki T, Kambe T, Nagao M, Hirose Y, Masuda S.
“Enhancing recombinant protein production in human cell lines with a constitutive transport element and mRNA export proteins”
J Biotechnol., 153, 86-91, 2011

神戸大朋
「生体機能における亜鉛トランスポーターの重要性
-亜鉛トランスポーターをめ ぐる 最近の知見-」
亜鉛栄養治療、1, 54-64, 2011

▼2010年


Yamazaki T, Fujiwara N, Yukinaga H, Ebisuya M, Shiki T, Kurihara T, Kioka N, Kambe T, Nagao M, Nishida E. and Masuda S
“The closely related RNA helicases, UAP56 and URH49, preferentially form distinct mRNA export machineries and coordinately regulate mitotic progression”
Mol. Biol. Cell, 21, 2953-2965, 2010

Fujiwara N, Yoshikawa M, Yamazaki T, Kambe T, Nagao M and Masuda S
“A Screening Method Tuned for mRNA Processing Factors in Human Cells by Evaluating the Luciferase Reporter Activity and the Subcellular Distribution of Bulk Poly(A)+ RNA”
Biosci. Biotechnol. Biochem., 74, 1512-1516, 2010

神戸大朋
「分泌経路において機能する亜鉛トランスポーター
-亜鉛酵素の活性化との関わり-」
Biomedical Research on Trace Elements-日本微量元素学会誌, 21, 25-31, 2010

福中彩子、神戸大朋
「亜鉛トランスポーターZnTとZIPの亜鉛輸送機構」
生化学, 80, 30-34, 2010

▼2009年


神戸大朋
「亜鉛トランスポーター研究から見た亜鉛バイオロジー」
Trace Nutrients Research-微量栄養素研究- 26, 11-16, 2009

White C, Lee J, Kambe T, Fritsche K, and Petris M. J
“A roll for the ATP7A copper-transporting ATPase in macrophage bactericidal activity”
J. Biol. Chem., 284, 33949-33956, 2009

Fukunaka A, Suzuki T, Kurokawa Y, Yamazaki T, Fujiwara N, Ishihara K, Migaki H, Okumura K, Masuda S, Yamaguchi-Iwai Y, Nagao M, and Kambe T
“Demonstration and characterization of the hetero-dimerization of ZnT5 and ZnT6 in the early secretory pathway”
J. Biol. Chem., 284, 30798-30806, 2009

神戸大朋
「亜鉛の生理機能を司る亜鉛トランスポーター」
化学と生物, 47, 545-552, 2009

Ohana E, Hoch E, Keisar C, Kambe T, Yifrach O, Hershfinkel M and Sekler I
“Identification of the Zn2+ binding site and mode of operation of a mammalian Zn2+ transporter”
J. Biol. Chem., 284, 17677-17686, 2009

Matsuura W, Yamazaki T, Yamaguchi-Iwai Y, Masuda S, Nagao M, Andrews G. K and Kambe T
“SLC39A9 (ZIP9) regulates zinc homeostasis in the secretory pathway: Characterization of the ZIP subfamily I protein in vertebrate cells”
Biosci. Biotechnol. Biochem., 73, 1142-1148, 2009

White C, Kambe T, Fulcher Y. G, Sachdev S. W, Bush A. I, Fritsche K, Lee J, Quinn T. P, and Petris M. J
“Copper transport into the secretory pathway is regulated by oxygen in macrophages”
J. Cell. Sci., 122, 1315-1321, 2009

神戸大朋
「Copper in Missouri and Zinc in Kansas-アメリカ中西部での微量金属研究」
化学と生物, 286-289, 2009

神戸大朋
「亜鉛代謝とアルコール発酵の関わり」
日本醸造協会誌, 104, 37-40, 2009

Kambe T, Andrews GK.
"Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (Slc39a4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations."
Mol Cell Biol. 29(1);129-139 (2009)

▼2008年


Kambe T, Geiser J, Lahner B, Salt D. E and Andrews G. K
“Slc39a1 to 3 (Subfamily II) Zip Genes in Mice have Unique Cell-Specific Functions during Adaptation to Zinc Deficiency”
Am. J. Physiol. Regul. Integr. Comp. Physiol. 294; 1474-1481 (2008)

Kambe T, Weaver B. P and Andrews G. K
"The Genetics of Essential Metal Homeostasis during Development
Genesis. 46; 214-228 (2008)

Ohashi, T., Matsui, T., Chujo, M., and Nagao, M.
“Restraint stress up-regulates expression of zinc transporter Zip14 mRNA in mouse liver.” Cytotechnol. 57, 1781-1785 (2008).

Zhu, H. L., Aishima, M., Morinaga, H., Wassall, R. D., Shibata, A., Iwasa, K., Nomura, M., Nagao, M., Sueishi, K.,, Cunnane, T. C, Teramoto, N.
“Molecular and biophysical properties of voltage-gated Na+ channels in murine vas deferens.” Biophys J. 94, 3340-3351 (2008).

Momma, K., Masuzawa Y., Nakai, N., Chujo, M., Murakami, A., Kioka, N., Kiyama, Y., Akita, T., and Nagao, M.
“Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament.” Cytotechnol. 56 (1) 33-39 (2008)

神戸大朋
「アルコール発酵と亜鉛」 
生物工学会誌, 86, 243, 2008

神戸大朋
「亜鉛トランスポーターとその分泌系における役割」
細胞工学 27; 231-236 (2008)

▼2007年


Weaver B. P, Dufner-Beattie J, Kambe T and Andrews G. K
“Novel zinc-responsive post-transcriptional mechanisms reciprocally regulate expression of the mouse Slc39a4 and Slc39a5 zinc transporters (Zip4 and Zip5)”
Biol. Chem. 388; 1301-1312 (2007)

神戸大朋
「分泌経路の恒常性維持に機能する亜鉛輸送体-亜鉛欠乏と小胞体ストレス 」
バイオサイエンスとインダストリー 65; 406-407 (2007)

▼2006年


Ishihara K, Yamazaki T, Ishida Y, Suzuki T, Oda K, Nagao M, Yamaguchi-Iwai Y, and Kambe T
“Zinc Transport Complexes Contribute to the Homeostatic Maintenance of Secretory Pathway Function in Vertebrate Cells” J. Biol. Chem. 281; 17743-17750 (2006)

Kambe T, Suzuki T, Nagao M and Yamaguchi-Iwai Y
“Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters”
Genomics, Proteomics & Bioinformatics, 4; 1-9 (2006)

▼2005年


Kambe T.
“Zinc transporters regulating zinc homeostasis in the secretory pathway”
Res. Adv.in Biological Chem. 3; 25-32 (2005)

Watanabe, D., Suzuma, K., Matsui, S., Kurimoto, M., Kiryu, J., Kita, M., Suzuma, I., Ohashi, H., Ojima, T., Murakami, T., Kobayashi, T., Masuda, S., Nagao, M., Yoshimura N. and Takagi, H.,
: Erythropoietin as a retinal angiogenic factor in proliferative diabetic retinopathy. New Engl. J. Med. 353; 782-792 (2005)

Suzuki T, Ishihara K, Migaki H, Matsuura W, Kohda A, Okumura K, Nagao M, Yamaguchi-Iwai Y, Kambe T.
Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases,
zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.
J Biol Chem. 280; 637-43 (2005)

Suzuki T, Ishihara K, Migaki H, Ishihara K, Nagao M, Yamaguchi-Iwai Y, Kambe T.
Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.
J Biol Chem. 280(35); 30956-62 (2005)

Murakami, K., Irie, K., Ohigashi, H., Hara, H., Nagao, M., Shimizu, T., and Shirasawa, T.
“Formation and stabilization model of the 42-mer Aβ radical: Implications for the long-lasting oxidative stress in Alzheimer’s disease.” J. Am. Chem. Soc. 127, 15168-15174 (2005).

Nagao, M., Wen, T-C., Okamoto, M., Irie, K., Takaku, T., and Sakanaka, M.
“In vivo neuroprotective activity of Epopeptide AB against ischemic damage.” Cytotechnol. 47, 139-144 (2005).

神戸大朋
「亜鉛輸送体による生体調節-hypozincemiaの発症機構」 
生物工学会誌, 83, 525 (2005)

▼2004年


Kambe, T., Yamaguchi-Iwai, Y., Sasaki R., and Nagao, M.
"Overview of mammalian zinc transporters."
Cell. Mol. Life Sci. 61; 49-68 (2004)

神戸大朋
「亜鉛サプリメントの取りすぎにはご用心」 
化学と生物 42; 393-394 (2004)